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Punch sticking, hardness stability, and high ejection force are among major problems encountered with tablet manufacturing process. This causes downtime in production and sometimes tablet defects.
Extensive tests were carried out with the iSpray – the external lubrication system from Pharma Technology as well as with another “well-known” supplier to demonstrate the effectiveness of the system to solve the 4 common problems regularly encountered:
A tablet press was equipped alternatively with the 2 types of external lubrication system:
iSpray – external lubrication system with following features:
Comparative equipment – external lubrication system with following features:
1°/Effect of the regularity of lubricant dosing on the tablet press ejection force
|iSpray 🡪 Very constant ejection force||Compared equipment 🡪 Strong disturbance of the ejection force|
2°/ Vacuuming of the exceed lubricant / dirtiness of the press / inconsistency in content & hardness
Constant dosing & constant hardness
Variable dosing & variability in hardness
3°/Benefit of the back-up line system (Not available on compared machine)
*Graphic shows a 3 second lubricant stop
🡪 Ensures a continuous process
The iSpray demonstrates clear advantages over existing technology. This advanced external lubrication system allows precise application of dry lubricant to the upper – lower punch tips and die wall. The result is that a very sticky granulation can be produced continuously, without any picking or sticking, and with lower ejection force. The iSpray technology opens the door to the production of formulations that contains little or no lubricant in the blend. The dosing and vacuum system of the iSpray is far superior to the compared equipment.
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