CUB-X – For OSD development & commercial production
The CUB-X is an innovative and versatile tablet inspection…
Why Is Automated High-Speed CQA Testing Critical for Modern Pharmaceuticals?
Today’s modern pharmaceutical OSD industry puts increasingly higher demands…
Exhibition | PCI Days – Warsaw, Poland – 21-22 June 2023
Come visit us during the Pharmaceutical and Cosmetic Industry…
What is the cornerstone of flawless IPC testing?
Advantages of In-process Quality Control Testing Atline In-process tablet…
PT Inc. doubles up its North American process equipment demonstration capacity !
PT Inc., the oral solid dose process equipment specialist…
Success Story | Mastering Production with an All-in-One Solution
"We had a challenging request: find a solution capable…
In the scope of 100% in-line quality control and real-time release of pharmaceutical tablets, the authors present a flexible inspection module for in-line tablet analysis with integrated multipoint near-infrared (NIR) spectroscopy and 3D microwave resonance technology (3D MRT). Via an industrial case study on Diclofenac Sodium tablets, the abilities of this versatile process analytical technology (PAT) tool are presented. It is demonstrated that the combination of Diclofenac concentration prediction via NIR spectroscopy and mass prediction via 3D MRT allow to estimate the dosage of each individual tablet. Single sample repetition tests were performed on 5 tablets, measured 10 times on three different days. A high accuracy and precision of prediction was shown, with an average standard deviation below 0.5 mg. The inspection run demonstrated the added value of such inspection and sorting strategies based on the calculated dosage of individual tablets.
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