CUB-X – For OSD development and commercial production

The CUB-X can measure tablet mass fraction for multiple ingredients – including moisture – at speeds up to 20.000 tablets/h using NIR-SRS spectroscopy, while tablets can be sampled at speeds up to 400 tablets/h for measurement of mass, thickness, diameter/length and hardness. This allows sampled tablets to be analyzed for porosity, dosage, and content uniformity, while all tablets are analyzed for API mass fraction.

EMBEDDED TECHNOLOGIES

• High-precision Tablet Laser Profiler

A laser line-scanning sensor profiles each tablet, while passing under the sensor, measuring its thickness with a precision of 50 µm. The tablet laser profiler also verifies the correct position and orientation of the tablet on the conveyor belt before it passes under the NIR-SRS sensor.

• NIR-SRS spectroscopy

Each tablet is inspected by the multipoint NIR-SRS (Near-Infra-Red Spatially Resolved Spectroscopy) probe at a high frame rate, allowing multiple spectral acquisitions per tablet. An accurate prediction of one or multiple ingredients’ mass fraction – including water – is then done by chemometric modelling. The SRS technology allows to cover a larger tablet surface and a deeper measurement penetration compared to single-point NIR reflection techniques, resulting in more accurate prediction of the CQA’s.

• Embedded high-speed 4P tablet testing

Samples can be sent to an embedded 4-parameter tablet tester at a rate of up to 400 tablets/h, measuring tablet mass, thickness, diameter/length, and hardness. The high sampling rate is achieved thanks to a purpose-designed sampling gate, which feeds tablets one by one directly to the measurement instruments